Wet White Mice

White-Footed and Deer Mice

Wet or dry: translatable "water mazes" for mice and humans.

Although the cognitive and biological characteristics of Alzheimer's disease (AD) are well known and mouse models of AD are available, current treatments for AD-related cognitive deficits have quite limited efficacy. The development of tasks with cross-species validity may enable better prediction of the efficacy of potential new treatments. In this issue of the JCI, Possin et al. present a vir...

Natural Spirillum Minus Infection in White Mice

Experimental Disseminated Encephalomyelitis in White Mice

Disseminated encephalomyelitis was readily induced in mice of the Swiss strain by means of repeated intramuscular and subcutaneous injections of apparently normal mouse brain mixed with an adjuvant. The latter consisted of autoclaved virulent tubercle bacilli and heavy liquid petrolatum, a modification of the Freund adjuvant. The syndrome and the histopathological picture of the induced malady ...

Third Borrelia Species in White-footed Mice

To the Editor: The white-footed mouse, Peromyscus leucopus, is a natural reservoir host of several pathogens, including Borrelia burgdorferi, an agent of Lyme borre-liosis (LB) (1). B. burgdorferi spiro-chetes are transmitted in the mouse population by Ixodes scapularis ticks. This tick vector also bears B. miyamo-toi, a sister species to the relapsing fever group of spirochetes (2,3). B. miyam...